Postdoctoral researcher protein-ligand interaction

28 dagen geleden

Arbeidsvoorwaarden

Standplaats:
Landelijk / geen vaste standplaats
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 uur
Salarisindicatie:
€ 2552 - € 3312 per maand
Opleidingsniveau:
Postdoctoraal

The recently established research group Plant Hormone Biology of the Swammerdam Institute for Life Sciences (SILS) is looking for a postdoctoral researcher with expertise in protein biochemistry, molecular biology and bioinformatics and/or protein modelling ...

Functieomschrijving

The recently established research group Plant Hormone Biology of the Swammerdam Institute for Life Sciences (SILS) is looking for a postdoctoral researcher with expertise in protein biochemistry, molecular biology and bioinformatics and/or protein modelling who will study the receptors involved in the perception of plant produced rhizosphere signalling molecules in plant enemies. He/she will co-supervise a PhD students working on this topic.

Perception of rhizosphere signalling will be investigated in two approaches, a low risk in parasitic plants and a high risk in a different plant enemy. Recent studies have identified D14like1 (or HTL) as the receptor for exogenous strigolactone perception in seeds of parasitic plants. However, nothing is known about what is determining strigolactone specificity in these parasitic plants. We will use a number of approaches such as yeast two hybrid (Y2H), Differential Scanning Fluorometry (DSF), protein complex isolation, modelling and mutant complementation studies to study the mechanism of strigolactone specificity in Striga and/or Orobanche species and ecotypes. Site-directed mutagenesis will be used to underpin the mechanism of changes in ligand specificity. For the high-risk approach we will use a different plant enemy that uses host produced signalling molecules and look for receptor candidates. The functionality and ligand specificity of candidate receptors and how they may have evolved will be studied using a range of different approaches.

Functie-eisen

We are looking for a team player, with good command of English, and expertise in protein biochemistry, molecular biology and bioinformatics. Affinity with protein modelling is an asset. You have a PhD in this field.

Conditions

The appointment will be on a temporary basis for a period of 1 year and after satisfactory evaluation can be extended with 2 more years to a total duration of 3 years. The candidate will co-supervise PhD student(s) and will be asked, in some cases, to assist in teaching of undergraduates. Based on a full-time appointment (38 hours per week) the gross monthly salary will be maximal €3,312 in the first year (scale 10-6) in the firsst year. The Collective Employment Agreement (CAO) for Dutch Universities is applicable.

Additional information

For further information you can contact:

Applications may only be submitted by electronic mail and should be sent to application-science@uva.nl. To enable us to process your application immediately, please quote vacancy number 17-207 and the position you are applying for in the subject-line.

Applications must include a curriculum vitae and a letter of motivation. Please combine these documents in one single attachment and also mention the months (not just years) in your CV when referring to your education and work experience.

Applications will be accepted until 22 May 2017.

Bedrijfsomschrijving

With over 5,000 employees, 30,000 students and a budget of more than 600 million euros, the University of Amsterdam (UvA) is an intellectual hub within the Netherlands. Teaching and research at the UvA are conducted within seven faculties: Humanities, Social and Behavioural Sciences, Economics and Business, Law, Science, Medicine and Dentistry. Housed on four city campuses in or near the heart of Amsterdam, where disciplines come together and interact, the faculties have close links with thousands of researchers and hundreds of institutions at home and abroad. The UvA’s students and employees are independent thinkers, competent rebels who dare to question dogmas and aren’t satisfied with easy answers and standard solutions. To work at the UvA is to work in an independent, creative, innovative and international climate characterised by an open atmosphere and a genuine engagement with the city of Amsterdam and society.

Swammerdam Institute for Life Sciences

The Swammerdam Institute for Life Sciences (SILS) is one of the largest institutes of the Faculty of Science of the University of Amsterdam (UvA). Some 240 members of staff organized in 16 research groups engage in excellent research into three themes, i.e. Cell & Systems Biology, Neurosciences and Molecular Life Sciences.

Within the Theme Molecular Life Sciences five research groups have dedicated their research to plants: Plant Physiology, Molecular Plant Pathology, Developmental Genetics, Plant Cell Biology and Plant Hormone Biology.

The recently established research group Plant Hormone Biology investigates the role of plant hormones and other signalling molecules in the communication of plants with other organisms. An example of these signalling molecules, which are used by plants for communication in the soil, are the strigolactones. These are used by the friends of plants, the symbiotic arbuscular mycorrhizal fungi, for host detection but also by their enemies, root parasitic plants. Parasitic plants are a major threat to agriculture in large parts of the world, and especially in the African continent where millet, maize and sorghum yields are severely affected by the witchweed, Striga hermonthica.

In a project funded by the Bill & Melinda Gates foundation, Promise, we will investigate with a number of partners in the Netherlands and United States, if the Striga problem can be tackled through the root microbiome of the host sorghum. With this and other funding (including an ERC Advanced grant) an international team of postdoctoral researchers, PhD’s and technicians with expertise varying from analytical chemistry to biochemistry to molecular biology will be working on a number of related topics pertaining to rhizosphere signalling.

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