PhD position Translational Research

27 dagen geleden

Arbeidsvoorwaarden

Standplaats:
Lundlaan, Utrecht, Utrecht
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 uur
Salarisindicatie:
€ 2567 per maand
Opleidingsniveau:
WO

The Princess Máxima Center is fully specialized in pediatric oncology. We are passionate about treating and curing children with cancer using the best possible methods. And we also want to prevent the development of negative ...

Functieomschrijving

The Princess Máxima Center is fully specialized in pediatric oncology. We are passionate about treating and curing children with cancer using the best possible methods. And we also want to prevent the development of negative side effects in young patients, both now and over the long term. Clinicians and researchers are working every day to improve the care and treatment. This is the only way that we can ensure that, in the future, at least nine out of ten children will recover from cancer under the best possible conditions.

Performing scientific research resulting in a PhD thesis on the topic Beating chromosome 21: small chromosome, large consequences in acute lymphoblastic leukemia.

Acute lymphoblastic leukemia is the most frequent type of cancer in children with a cure rate over 80% after intensive chemotherapy; however, treatment-related toxicity and relapses necessitate research to identify biomarkers that indicate sensitivity to more specific drugs. Our research group aims to develop novel treatment strategies for high-risk pediatric leukemia patients by translating genetic events into molecular targets.

One of the most frequent genetic events in pediatric leukemia is gain of chromosome 21. In a KWF-granted project, we will identify deregulated genes and cooperative genetic lesions to provide a rationale to better treat leukemic patients with chromosome 21 aberrations. The project will involve DNA and RNA sequencing of different groups of patient samples with chromosome 21 aberrations and integration of genetic data with gene expression data. The oncogenic role of the resulting candidate genes will be evaluated in functional genomics experiments, and the effect of drugs inhibiting these oncogenes will be tested on leukemic patients’ cells.

Functie-eisen

We are looking for an enthusiastic and highly motivated researcher with a MSc degree in biomedical sciences, medicine, medical biology or a related field in molecular sciences and a passion for genomics data. Our group welcomes candidates who have a natural level of scientific thinking, who are curious and are eager to learn. Candidates are required to have excellent communicative skills and a good command of oral and written English. Although a level of independence is expected, you should be motivated to work in a multidisciplinary team. You are enthusiastic to supervise students and to share your knowledge with other researchers.

Conditions

We offer a challenging PhD project in a social and ambitious research group. The total duration of the project is 4 years (full-time). You will initially be appointed for a period of 1 year, after which your performance will be evaluated. The project will start at the Laboratory of Pediatric Oncology of Erasmus Medical Center in Rotterdam, and continue at the Princess Máxima Center for Pediatric Oncology in Utrecht mid 2018.

Your salary is being fixed according to scale equivalents in the collective labour agreement excluding 8% holiday allowance and an 8,3% year-end bonus. The gross salary will be 2.567 euro per month according to scale equivalent 22, starting from a 36-our working week.

Additional information

For more information please contact Dr. J.M. Boer (tel.: 010-7038264; j.m.boer@erasmusmc.nl or Prof.dr. M.L. Den Boer (tel.: 010-7043936; e-mail: m.l.denboer@erasmusmc.nl).

This vacancy has been published via SciencePlatform, launched by NRC Carrière and AcademicTransfer.

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