PhD in Chemical Biology

ongeveer een maand geleden

Arbeidsvoorwaarden

Standplaats:
Bornsesteeg, Wageningen, Gelderland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 - 38 uur
Opleidingsniveau:
WO

The Laboratory of Organic Chemistry (ORC) of Wageningen University & Research is looking for a PhD student (AIO) on an NWO-funded ECHO-project entitled "Trigger-Responsive Protein Modification using Switchable DNA Devices." Controlled modification of native proteins ...

Functieomschrijving

The Laboratory of Organic Chemistry (ORC) of Wageningen University & Research is looking for a PhD student (AIO) on an NWO-funded ECHO-project entitled "Trigger-Responsive Protein Modification using Switchable DNA Devices." Controlled modification of native proteins is an essential tool to tailor specific properties, e.g. for industrial application (biocatalysis), as therapeutics, or to study proteins in their native habitat (chemical biology). In this project we will develop novel methods for the site-selective and trigger-dependent modification of proteins with nanostructured molecular devices based on synthetic DNA strands. The DNA devices will contain a protein-binding domain and a catalytic domain that can generate reactive molecules that attach themselves to the protein. By dictating the distance between the protein and the catalytic domain, it may be envisaged that both the site and the degree of the modification can be specified. Another goal is to obtain a switchable tool for protein-modification efficiency by bringing the DNA device selectively in an ON or OFF-state, in order to mimic Nature's method of modulation of protein activity. We aim to develop next generation tools that modify proteins and their functions by chemo- and site-selective modification in the presence of an inducer. This should show broad applicability of the concept, and propel it into the field of chemical biology, as well as diagnostic and therapeutic directions.

This project will be performed in collaboration with prof. dr. Floris van Delft (special professor Bioconjugate Chemistry at ORC, founder and CSO of Synaffix). The project will mainly be performed at the Laboratory of Organic Chemistry in Wageningen, and will be embedded in the Graduate School VLAG.

Functie-eisen

MSc degree (or equivalent) in Organic Chemistry, or comparable curriculum. A strong background and solid hands-on experience in synthetic organic chemistry and biochemistry is essential. In addition, practical experience with various analytical techniques such as SDS-PAGE, HPLC, LC-MS, and various spectroscopic techniques is a strong advantage. Furthermore, you should have good written and oral communication skills in English.

Conditions

We offer you a temporary position for a period of 1.5 years with extension of 2.5 years after successful evaluation. Gross salary per month € 2191,- in the first year rising up to € 2801,- per month in the fourth year.

We not only offer a competitive salary but also good (study) leave and a pension of the ABP Pension Fund.

Additional information

For more information about this position, please contact Bauke Albada, Lab of Organic Chemistry, Wageningen University & Research, e-mail: bauke.albada@wur.nl.

For more information about the contractual aspects, please contact Mrs. N. de Vries (HR-advisor), telephone number +31 317485677 .

Interested?
You can apply online at www.wur.nl/en/Jobs/Vacancies.htm until 30 April 2017.

Bedrijfsomschrijving

The Laboratory of Organic Chemistry (www.orc.wur.nl), headed by prof. Han Zuilhof, constitutes a large and interdisciplinary research team. Within this lab, we have a vibrant line of research in which we apply novel approaches for the site-selective modification of bioactive proteins. Our new (opened 2016!) laboratories are extremely well-equipped for organic chemistry, with a very wide range of instruments for analysis of biomolecules and surfaces, for which we also employ an extended experienced technical staff. Embedding within Wageningen University & Research provides additional biological input. We are also involved in teaching and currently ca. 1600 students each year take part in one or more of the group's courses.

The Agrotechnology & Food Sciences Group is part of Wageningen University & Research where fundamental and applied sciences complement each other. As an important European player, we carry out top-level research and work alongside authoritative partners within the international business world as well as the government on "Healthy food in a biobased society". We have a crucial role in innovations within the market. Entrepreneurship and professionalism are what define us. In short, we are an interesting, international employer of stature.

Wageningen University & Research
Delivering a substantial contribution to the quality of life. That's our focus - each and every day. Within our domain, healthy food and living environment, we search for answers to issues affecting society - such as sustainable food production, climate change and alternative energy. Of course, we don't do this alone. Every day, 5000 people work on 'the quality of life', turning ideas into reality, on a global scale.

Could you be one of these people? We give you the space you need.

For further information about working at Wageningen University & Research, take a look at www.wur.nl/en/Jobs.htm

Acquisition regarding this vacancy is not appreciated.

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